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Refrigerant of 4xx series, e.g. R-404a are non azeotrope type refrigerants, EXCEPT for R-410.R-410 is a near azeotrope mixture. Azeotrope refrigerants consist of more than one blend of refrigerants, but it acts like a single refrigerant. Non azeotrope refrigerants on the other hand, DO NOT act like a single refrigerant.You cannot add a charge to a non-azeotrope refrigerant system. If low, the remaining refrigerant needs to be completely evacuated and the system has to be charged again from zero. This is because of the physical properties of the different chemicals being lost from the system at different rates. The blends will be lost from the system at different proportions due to different boiling temperatures, whenever there is a leakage in the non azeotrope refrigerant.Azeotrope, or near azeotrope blends will act as a single refrigerant, and therefore, may be topped up in case of refrigerant leakage. R-410A, just like R-22 can be topped up.