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'''Serial Port Access in Wine is Problematic at best, even in Wine version 9.'''After doing chmod 666 /dev/ttyUSB0 and editing ~/.wine/system.reg then restarting the ~/.wine/system.reg edits manually made were gone and new entries for serial ports became available. An entire section looking like this: [Hardware\\Devicemap\\Serialcomm] 1708127074 "\\Device\\Serial0"="COM1" "\\Device\\Serial1"="COM2" "Serial0"="COM1"Except with many more entries than this sample was auto generated.Just "some" software executed in wine will see the serial port if it can be manually entered into the software. Still very flakey!The resource [https://www.onetransistor.eu/2015/12/wine-serial-port-linux.html Set up the serial port in Wine] was probably the most helpful. * https://forums.linuxmint.com/viewtopic.php?t=412636